MovDisordV3, Main, Exploration, bibRecord, 004E90

The Subthalamic Nucleus and Tremor in Parkinson's Disease

Identifieur interne : 004E90 ( Main/Exploration ); précédent : 004E89; suivant : 004E91

The Subthalamic Nucleus and Tremor in Parkinson's Disease

Auteurs : M. C. Rodriguez [Espagne] ; Oroz J. Guridi [Espagne] ; L. Alvarez [Cuba] ; K. Mewes [Cuba] ; R. Macias [Cuba] ; J. Vitek [États-Unis] ; M. R. Delong [États-Unis] ; J. A. Obeso [Espagne]

Source :

Movement Disorders [ 0885-3185 ] ; 1998.

RBID : ISTEX:5E92EBD3F6DA02DA0AAE959C498DA869B5D8806A

Descripteurs français

Pascal (Inist)
- Bilatéral, Electrocoagulation, Etude comparative, Homme, Long terme, Noyau sousthalamique, Parkinson maladie, Pathogénie, Pronostic, Sousthalamotomie, Stimulus électrique, Traitement, Tremblement, Unilatéral.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Bilateral, Comparative study, Deep‐brain stimulation, Electric Stimulation (methods), Electrical stimulus, Electrocoagulation, Female, Human, Humans, Long term, Male, Middle Aged, Monitoring, Intraoperative, Parkinson Disease (complications), Parkinson disease, Parkinsonian tremor, Pathogenesis, Postoperative Period, Preoperative Care, Prognosis, Subthalamic nucleus, Subthalamotomy, Thalamic Nuclei (surgery), Treatment, Tremor, Tremor (etiology), Tremor (therapy), Unilateral.
MESH :
- complications : Parkinson Disease.
- etiology : Tremor.
- methods : Electric Stimulation.
- surgery : Thalamic Nuclei.
- therapy : Tremor.
- Adult, Aged, Female, Humans, Male, Middle Aged, Monitoring, Intraoperative, Postoperative Period, Preoperative Care.

Abstract

The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor. We recorded tremor‐related activity in the STN in 12 patients with Parkinson's disease (PD) and found that microstimulation of the sensorimotor region of the nucleus, where these neurons are present, stopped the tremor with a very short latency. Long‐term treatment by means of bilateral deep‐brain stimulation (DBS) in the same 12 patients led to a significant reduction of tremor as well as other cardinal features of PD. This effect was blindly assessed at 3 months after implantation. In another group of seven patients, a unilateral lesion of the STN was performed. Both postural and resting tremor were significantly improved on the limbs contralateral to the lesion side. In three patients, tremor disappeared completely after 12 months of follow up. The electrophysiologic data and therapeutic effect of inactivating the STN strongly indicated that this structure is directly involved in the origin of parkinsonian tremor, as suggested by the MPTP model.

Url:

https://api.istex.fr/document/5E92EBD3F6DA02DA0AAE959C498DA869B5D8806A/fulltext/pdf

DOI: 10.1002/mds.870131320

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor. We recorded tremor‐related activity in the STN in 12 patients with Parkinson's disease (PD) and found that microstimulation of the sensorimotor region of the nucleus, where these neurons are present, stopped the tremor with a very short latency. Long‐term treatment by means of bilateral deep‐brain stimulation (DBS) in the same 12 patients led to a significant reduction of tremor as well as other cardinal features of PD. This effect was blindly assessed at 3 months after implantation. In another group of seven patients, a unilateral lesion of the STN was performed. Both postural and resting tremor were significantly improved on the limbs contralateral to the lesion side. In three patients, tremor disappeared completely after 12 months of follow up. The electrophysiologic data and therapeutic effect of inactivating the STN strongly indicated that this structure is directly involved in the origin of parkinsonian tremor, as suggested by the MPTP model.</div>
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Movement Disorders (revue)

The Subthalamic Nucleus and Tremor in Parkinson's Disease

The Subthalamic Nucleus and Tremor in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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